Dexdomitor 0.5

Dexdomitor 0.5Nplooj ntawv no muaj cov ntaub ntawv ntawm Dexdomitor 0.5 rau siv tsiaj .
Cov ntaub ntawv muab feem ntau suav nrog cov hauv qab no:
  • Dexdomitor 0.5 Qhov taw qhia
  • Lus ceeb toom thiab ceeb toom rau Dexdomitor 0.5
  • Cov lus qhia thiab ntau npaum li cas rau Dexdomitor 0.5

Dexdomitor 0.5

Qhov kev kho mob no siv rau cov tsiaj hauv qab no:
Tuam txhab: Zoetis

PACKAGE INSERT

(dexmedetomidine hydrochloride)



Sterile Txhaj Tshuaj - 0.5 mg/mL



Intramuscular and Intravenous use in Dogs

Kev siv tshuaj intramuscular hauv miv



Sedative, Analgesic, Preanesthetic

NADA 141-267, Pom zoo los ntawm FDA.

Dexdomitor 0.5 Ceev faj

Tsoomfwv txoj cai txwv tsis pub siv cov tshuaj no los ntawm lossis txiav txim ntawm tus kws kho tsiaj muaj ntawv tso cai.



Nqe lus piav qhia

DEXDOMITOR (dexmedetomidine hydrochloride) yog cov khoom siv hluavtaws alpha2-adrenoreceptor agonist nrog sedative thiab analgesic zog. Lub npe tshuaj yog (±) -4- [1- (2,3-dimethylphenyl) ethyl] -1H-imidazole monohydrochloride. Nws yog xim dawb, lossis yuav luag dawb, crystalline, dej cov tshuaj yaj ywm muaj lub cev hnyav ntawm 236.7. Cov mis mos molecular yog C.13H16N2• HCl thiab cov qauv txheej txheem yog:

Txhua ml ntawm DEXDOMITOR muaj 0.5 mg dexmedetomidine hydrochloride, 1.6 mg methylparaben (NF), 0.2 mg propylparaben (NF), 9.0 mg sodium chloride (USP), thiab dej rau txhaj (USP), q.s.

Dexdomitor 0.5 Qhov taw qhia

DEXDOMITOR tau qhia rau siv ua sedative thiab analgesic hauv dev thiab miv los pab txhawb kev kuaj mob, txheej txheem kho mob, txheej txheem phais me me, thiab txheej txheem kho hniav me. DEXDOMITOR kuj tseem tau qhia rau siv ua tshuaj loog ua ntej siv tshuaj loog hauv dev thiab miv.

Dosage thiab Administration

Aub: Sedation thiab Analgesia: 500 mcg/m 2 intramuscularly (IM) lossis 375 mcg/m 2 intravenously (IV). Preanesthesia: 125 lossis 375 mcg/m 2 Nyob rau hauv.

Kev xaiv cov tshuaj preanesthetic nyob ntawm lub sijhawm thiab qhov hnyav ntawm cov txheej txheem, nrog rau kev siv tshuaj loog. Ob lub rooj hauv qab no tuaj yeem siv los txiav txim qhov tseeb dexmedetomidine ntau npaum li cas. Nco ntsoov tias cov tshuaj mcg/kg txo raws li lub cev hnyav nce. Piv txwv li, cov dev hnyav 2 kg tau txhaj ntawm 28.1 mcg/kg dexmedetomidine IV, piv rau cov dev hnyav 80 kg uas tau txhaj ntawm 8.7 mcg/kg. Vim tias kev tswj hwm me me, kev siv tshuaj kom raug yog ua tsis tau rau cov dev uas hnyav dua 2 kg (4.4 lb).

Table 1: CANINE SEDATION/ANALGESIA DOSE TABLE: Tshuaj txhaj tshuaj (IV) thiab txhaj tshuaj intramuscular (IM) raws lub cev hnyav.

DEXDOMITOR 0.5 mg/mL

Sedation/analgesia hauv dev

Aub Nyhav

Dexmedetomidine 375 mcg/m22IV

Dexmedetomidine 500 mcg/m.2Nyob rau hauv

lb ua

Kg

mcg/kg ib

ml ua

mcg/kg ib

ml ua

4.4-7

2-3

28.1

0.12

40

0.15

7.1-9

3.1-4

25

0.15

35

0.2

9.1-11

4.1-5

2.3

0.2

30

0.3

11.1-22

5.1-10

19.6

0.29

25

0.4

22.1-29

10.1-13

16.8

0.38

2.3

0.5

29.1-33

13.1-15

15.7

0.44

nees nkaum ib

0.6

33.1-44

15.1-20

14.6

0.51

nees nkaum

0.7

44.1-55

20.1-25

13.4

0.6

18

0.8

55.1-66

25.1-30

12.6

0.69

17

0.9

66.1-73

30.1-33

12

0.75

16

1

73.1-81

33.1-37

11.6

0.81

kaum tsib

1.1

81.1-99

37.1-45

kaum ib

0.9

14.5

1.2

99.1-110

45.1-50

10.5

0.99

14

1.3

110.1-121

50.1-55

10.1

1.06

13.5

1.4

121.1-132

55.1-60

9.8

1.13

13

1.5

132.1-143

60.1-65

9.5

1.19

12.8

oval ntsiav tshuaj dawb ip 204

1.6

143.1-154

65.1-70

9.3

1.26

12.5

1.7

154.1-176

70.1-80

9

1.35

12.3

1.8

> 176

> 80

8.7

1.42

12

1.9

Table 2: CANINE PREANESTHESIA DOSE TABLE: Intramuscular (IM) noj tshuaj raws lub cev hnyav.

DEXDOMITOR 0.5 mg/mL

Preanesthesia hauv dev

Aub Nyhav

Dexmedetomidine 125 mcg/m22Nyob rau hauv

Dexmedetomidine 375 mcg/m22Nyob rau hauv

lb ua

Kg

mcg/kg ib

ml ua

mcg/kg ib

ml ua

4.4-7

2-3

9.4

0.04

28.1

0.12

7.1-9

3.1-4

8.3

0.05

25

0.15

9.1-11

4.1-5

7.7

0.07

2.3

0.2

11.1-22

5.1-10

6.5

0.1

19.6

0.29

22.1-29

10.1-13

5.6

0.13

16.8

0.38

29.1-33

13.1-15

5.2

0.15

15.7

0.44

33.1-44

15.1-20

4.9

0.17

14.6

0.51

44.1-55

20.1-25

4.5

0.2

13.4

0.6

55.1-66

25.1-30

4.2

0.23

12.6

0.69

66.1-73

30.1-33

4

0.25

12

0.75

73.1-81

33.1-37

3.9

huab cua yog dab tsi

0.27

11.6

0.81

81.1-99

37.1-45

3.7

0.3

kaum ib

0.9

99.1-110

45.1-50

3.5

0.33

10.5

0.99

110.1-121

50.1-55

3.4

0.35

10.1

1.06

121.1-132

55.1-60

3.3

0.38

9.8

1.13

132.1-143

60.1-65

3.2

0.4

9.5

1.19

143.1-154

65.1-70

3.1

0.42

9.3

1.26

154.1-176

70.1-80

3

0.45

9

1.35

> 176

> 80

2.9

0.47

8.7

1.42

Kev siv dexmedetomidine ua qhov ua kom zoo nkauj ua ntej txo qis kev ua kom loog hauv dev. Kev txhaj tshuaj yuav tsum tau txhaj tshuaj intubation yuav raug txo ntawm 30% thiab 60%, nyob ntawm seb xaiv tshuaj loog thiab dexmedetomidine preanesthetic koob tshuaj. Kev mloog zoo ntawm kev nqus cov tshuaj ua kom loog yuav raug txo ntawm 40% thiab 60%, nyob ntawm qhov koob tshuaj dexmedetomidine. Cov tshuaj loog tshuaj yuav tsum tau muab tso ua ntu zus tiv thaiv tus neeg mob cov lus teb. Kev xaiv tshuaj loog yog sab laug rau kev txiav txim siab ntawm tus kws kho tsiaj.

Miv: Sedation, Analgesia thiab Preanesthesia: 40 mcg/kg intramuscularly (IM).

Qhov koob tshuaj no tseem tuaj yeem siv ua qhov ua kom zoo nkauj thiab tau qhia rau ua kom txo qis cov tshuaj loog hauv miv . Kev txhaj tshuaj ua kom loog xav tau rau intubation tau txo mus txog 49%, nyob ntawm qhov xaiv cov tshuaj induction. Qhov siab ntawm kev nqus cov tshuaj ua kom loog tau txo qis ntawm 35% thiab 44%, nyob ntawm qhov xaiv cov tshuaj induction. Cov tshuaj loog tshuaj yuav tsum tau muab tso ua ntu zus tiv thaiv tus neeg mob cov lus teb.

Cov lus hauv qab no tuaj yeem siv los txiav txim qhov tseeb dexmedetomidine ntau npaum rau miv raws li lub cev hnyav.

Table 3: FELINE DOSE TABLE: Intramuscular (IM) noj tshuaj raws lub cev hnyav hauv miv.

DEXDOMITOR 0.5 mg/mL

Sedation/analgesia thiab preanesthesia hauv miv

Miv Nyhav

Dexmedetomidine 40 mcg/kg IM

lb ua

kg ua

mcg/kg ib

ml ua

2-4

1-2

40

0.1

4.1-7

2.1-3

40

0.2

7.1-9

3.1-4

40

0.3

9.1-13

4.1-6

40

0.4

13.1-15

6.1-7

40

0.5

15.1-18

7.1-8

40

0.6

18.1-22

8.1-10

40

0.7

Nws tau pom zoo kom yoo mov rau miv thiab miv rau 12 teev ua ntej kho nrog DEXDOMITOR. Lub qhov muag lub qhov muag yuav tsum tau siv rau miv txhawm rau tiv thaiv kom lub qhov muag qhuav qhuav uas tuaj yeem tshwm sim los ntawm kev txo qis ntawm qhov muag ntsais muag. Tom qab txhaj tshuaj DEXDOMITOR, tus tsiaj yuav tsum tau tso cai kom so ntsiag to li 15 feeb; sedation thiab analgesia tshwm sim li ntawm 5 txog 15 feeb, nrog cov txiaj ntsig siab tshaj ntawm 30 feeb tom qab dexmedetomidine.

Contraindications

Tsis txhob siv DEXDOMITOR hauv cov dev lossis miv uas muaj kab mob hauv lub plawv, ua tsis taus pa, mob siab lossis mob raum, lossis nyob rau qhov xwm txheej ntawm kev poob siab, tsis muaj zog, lossis muaj kev ntxhov siab vim kub heev, txias lossis qaug zog.

Raws li nrog txhua tus alpha2-adrenoceptor agonists, muaj peev xwm cais cov neeg mob ntawm qhov ua tsis tau zoo, suav nrog cov lus teb tsis sib xws (ua kom zoo siab), muaj.

Lus ceeb toom

Tib neeg kev nyab xeeb: Tsis yog rau tib neeg siv. Tsis txhob ncav cuag cov menyuam.

Dexmedetomidine hydrochloride tuaj yeem nqus tau tom qab kis tau ncaj qha rau ntawm daim tawv nqaij, qhov muag, lossis qhov ncauj, thiab tuaj yeem ua rau khaus. Thaum raug qhov muag raug qhov muag, yaug nrog dej li 15 feeb. Thaum raug ntawm daim tawv nqaij raug mob, ntxuav nrog xab npum thiab dej. Tshem cov khaub ncaws tsis huv.

Kev tiv thaiv tsim nyog yuav tsum tau ua thaum tuav thiab siv cov koob txhaj tshuaj. Kev raug xwm txheej (suav nrog qhov muag) raug, qhov ncauj tawm, lossis raug los ntawm kev txhaj tshuaj tuaj yeem ua rau muaj kev phiv tshuaj, suav nrog ua kom lub cev tsis muaj zog, hypotension, thiab bradycardia. Nrhiav kev kho mob tam sim.

Cov neeg siv cov kab mob plawv (piv txwv li, mob ntshav siab lossis mob plawv ischemic) yuav tsum tau ceev faj tshwj xeeb kom tsis txhob muaj kev cuam tshuam rau cov khoom no.

Ceev faj yuav tsum tau ua thaum tuav cov tsiaj sedated. Kev tuav tes lossis lwm yam kev txhawb zog tam sim ntawd, suav nrog suab nrov, tuaj yeem ua rau muaj kev tiv thaiv tiv thaiv tus tsiaj uas zoo li hnyav heev.

Cov ntaub ntawv kev nyab xeeb ntawm cov ntaub ntawv (MSDS) muaj cov ncauj lus ntxaws ntxaws txog kev nyab xeeb ntawm kev ua haujlwm. Txhawm rau tshaj tawm cov kev tsis zoo hauv cov neeg siv lossis kom tau txais daim ntawv theej ntawm MSDS rau cov khoom no hu rau 1-888-963-8471.

Nco tseg rau tus kws kho mob: Cov khoom no muaj alpha2-adrenergic agonist.

Kev nyab xeeb tsiaj: Dexmedetomidine yuav tsum tsis txhob siv thaum muaj cov tsos mob hypotension yav dhau los, hypoxia, lossis bradycardia. Vim hais tias muaj txiaj ntsig zoo ntawm kev mob plawv ntawm dexmedetomidine, tsuas yog cov chaw noj qab haus huv dev thiab miv (ASA chav kawm I thiab II) yuav tsum tau kho. Tsiaj txhu yuav tsum tau saib xyuas tas li rau kev ua haujlwm ntawm lub plawv thiab lub cev kub thaum ua kom loog lossis ua kom loog. Dexmedetomidine sedation tsis pom zoo rau cov miv uas muaj kab mob ua pa.

Kev siv dexmedetomidine ua qhov ua kom zoo nkauj hauv cov dev thiab miv tau txo qis tus nqi induction thiab kho cov tshuaj loog uas xav tau. Ua tib zoo saib xyuas tus neeg mob thaum lub sijhawm ua kom loog thiab kho yog tsim nyog kom tsis txhob siv tshuaj loog ntau dhau.

taub dag noob roj ntau npaum li cas

Cov kev ceev faj

Apnea yuav tshwm sim nrog kev siv dexmedetomidine. Thaum muaj mob apnea, yuav tsum tau muab cov pa oxygen ntxiv. Kev tswj hwm ntawm ANTISEDAN (atipamezole) rau cov dev yog lav thaum apnea nrog bradycardia thiab cyanotic mucous membranes.

Cov lus ceeb toom tsis zoo rau dexmedetomidine hauv miv suav nrog cov xwm txheej tsis xwm yeem ntawm kev ua pa hnyav thiab ua pa nyuaj ua pa raws li mob ntsws loj. Dyspnea vim qhov pib qeeb ntawm cov hlab ntsws tuaj yeem tshwm sim hauv qhov xwm txheej tsis tshua muaj txog peb hnub tom qab dexmedetomidine tswj hwm. Qee qhov ntawm cov mob hnyav thiab qeeb ntawm cov ntsws ua rau ua rau tuag txawm hais tias qhov no tsis tau pom hauv kev tshawb fawb hauv tsev kho mob feline nrog dexmedetomidine.

Hauv cov dev, intramuscular ANTISEDAN (atipamezole) tuaj yeem siv ua ntu zus kom thim rov qab los ntawm dexmedetomidine. Txij li thaum analgesic nrog rau cov teebmeem sedative yuav thim rov qab, kev tswj qhov mob yuav xav tau hais qhia.

Hauv miv, ANTISEDAN (atipamezole) tsis tau raug tshuaj xyuas raws li tus neeg ua haujlwm dexmedetomidine thim rov qab. Hauv miv, cov xwm txheej ntawm dyspnea tom qab ANTISEDAN (atipamezole) cov thawj coj tau tshaj tawm.

Dexmedetomidine tsis tau tshuaj xyuas thaum muaj lwm yam kev ua kom zoo nkauj hauv miv. Txawm hais tias tsis tau pom nyob hauv kev tshawb fawb feline, kev tuag tau tshaj tawm hauv miv tau txais dexmedetomidine ua ke nrog ketamine thiab butorphanol.

Analgesia tshwm sim los ntawm preanesthetic dexmedetomidine yuav tsis muab kev tswj kom tsim nyog thaum lub sijhawm ua haujlwm tom qab lossis tom qab txheej txheem. Kev tswj qhov mob ntxiv yuav tsum tau hais raws li xav tau.

Tom qab kev tswj hwm ntawm dexmedetomidine, qhov txo qis hauv lub cev kub yuav tshwm sim tshwj tsis yog muaj kev saib xyuas sab nraud. Thaum tsim tau lawm, kev sov siab tuaj yeem nyob ntev dua li kev ua kom loog thiab ua kom loog. Txhawm rau tiv thaiv kev kub taub hau, kho cov tsiaj yuav tsum tau sov thiab nyob rau qhov kub tas li thaum lub sijhawm txheej txheem, thiab kom txog thaum rov zoo.

Nervous lossis zoo siab cov tsiaj nrog qib siab ntawm endogenous catecholamines tuaj yeem nthuav tawm cov lus teb tshuaj txo qis rau alpha2-adrenoceptor agonists zoo li dexmedetomidine (tsis muaj txiaj ntsig). Hauv cov tsiaj ntxhov siab, qhov pib ntawm kev ua kom sedative/analgesic tuaj yeem ua qeeb, lossis qhov tob thiab ntev ntawm cov teebmeem tuaj yeem ploj lossis tsis muaj. Yog li ntawd, cia dev thiab miv so ntsiag to li 10 txog 15 feeb tom qab txhaj tshuaj. Kev rov ua dua koob tshuaj tsis tau tshuaj xyuas.

Kev tswj hwm cov tshuaj anticholinergic hauv dev lossis miv nyob rau tib lub sijhawm lossis tom qab dexmedetomidine tuaj yeem ua rau muaj kev cuam tshuam tsis zoo rau lub plawv (tachycardia thib ob, mob ntshav siab ntev, thiab lub plawv dhia tsis xwm yeem)1,2,3, ib). Txawm li cas los xij, cov tshuaj anticholinergic tuaj yeem siv rau cov dev tsawg kawg 10 feeb ua ntej dexmedetomidine rau kev tiv thaiv ntawm dexmedetomidine-txo qis hauv lub plawv dhia. Yog li ntawd, niaj hnub siv tshuaj tiv thaiv kab mob anticholinergics ib txhij nrog, lossis tom qab dexmedetomidine hauv dev lossis miv, tsis pom zoo (saib ANIMAL SAFETY).

Cov leeg nqaij sib tw (twitching) tuaj yeem xav tau hauv qee cov dev sedated nrog dexmedetomidine.

Dexmedetomidine tau tshuaj xyuas tsuas yog hauv cov dev yoo mov; yog li ntawd, nws cov txiaj ntsig ntawm pub dev (piv txwv li, qhov tshwm sim ntuav) tsis tau muaj tus yam ntxwv. Hauv miv, muaj qhov ntuav ntau zaus txawm tias pub mis lossis yoo mov; yog li ntawd, yoo mov tau pom zoo kom txo cov ntsiab lus hauv plab.

Dexmedetomidine tsis tau tshuaj xyuas hauv cov dev uas muaj hnub nyoog qis dua 16 lub lis piam, hauv cov miv uas muaj hnub nyoog qis dua 12 lub lis piam, lossis hauv cov dev laus thiab miv.

Dexmedetomidine tsis tau tshuaj xyuas rau kev siv hauv kev yug me nyuam, cev xeeb tub, lossis pub mis dev lossis miv.

Cov Teeb Meem Tsis Zoo

Canine sedation/analgesia kawm tshawb fawb: Hauv kev tshuaj xyuas kev nyab xeeb hauv tebchaws, 106 tus dev tau txais dexmedetomidine thiab 107 tau txais medetomidine. Cov dev sib txawv ntawm 16 lub lis piam mus rau 16 xyoos, sawv cev rau 49 hom tsiaj. Cov lus hauv qab no qhia txog tus naj npawb ntawm cov dev pom txhua qhov kev soj ntsuam soj ntsuam (qee tus dev tau ntsib ntau dua ib qho kev tsis zoo).

Rooj 4: Cov kev tsis zoo tshwm sim thaum kawm canine sedation/analgesia kev kawm

Dexmedetomidine Total n = 106

Medetomidine Total n = 107

Ausculted tsis paub meej arrhythmias

19

nees nkaum

Mob hnyav bradycardia xav tau kev kho mob

1

1

Apnea xav tau kev kho mob

1

0

Kev pib qeeb ntawm sedation (ntau dua 30 feeb)

1

1

Tsis muaj txiaj ntsig (dev sawv thoob plaws txoj kev kawm)

3

2

Kev mob hypothermia hnyav uas xav tau kev kho mob

2

0

Ntev rov zoo

1

4

Qhov tshwm sim ntawm ausculted arrhythmias tsis paub (qee qhov ntawm ntau lub ntsiab lus lub sijhawm) poob qis tom qab kev tswj hwm ntawm atipamezole.

Canine preanesthesia teb kawm: Kev tshuaj xyuas kev nyab xeeb ntawm thaj tsam preanesthesia suav nrog 192 tus dev, nruab nrab ntawm 5 hlis thiab 15 xyoos, sawv cev rau 43 hom tsiaj uas tau cuv npe rau cov txheej txheem xaiv uas tau ua hauv kev tshuaj loog dav. Cov lus hauv qab no qhia txog tus naj npawb ntawm cov dev hauv pab pawg kho mob uas tau qhia rau txhua qhov chaw kuaj mob (dev tej zaum yuav tau ntsib ntau dua ib qho kev tsis zoo).

Table 5: Kev tsis zoo tshwm sim thaum kawm canine preanesthesia

Pawg Kho Mob

Induction Tshuaj loog:

Propofol

Barbiturate

Preanesthetic Dose:

0 mcg/feeb2n = 32 hli

125 mcg/feeb2n = 32 hli

375 mcg/teev2n = 32 hli

0 mcg/feeb2n = 32 hli

125 mcg/feeb2n = 32 hli

375 mcg/teev2n = 32 hli

Emesis

4

7

4

2

3

6

Ventricular ntxov ntxov contractions

0

2

0

4

1

0

Raws plab

1

0

0

3

1

1

Tus kheej raug mob

0

2

1

2

1

0

Mob hnyav bradycardia

0

0

1

0

0

1

Tachycardia

0

0

0

1

1

0

Cov zis tsis txaus

0

0

0

0

0

1

Lwm cov tsos mob pom hauv dev kho nrog dexmedetomidine suav nrog ua pa luv thiab ua kom sov sov.

Feline sedation/analgesia kev kawm: Kev tshawb fawb txog kev nyab xeeb suav nrog 242 miv (122 tau txais dexmedetomidine; 120 tau txais xylazine), 6 lub hlis txog 17 xyoos, thiab sawv cev rau 19 hom tsiaj. Cov lus hauv qab no qhia txog pes tsawg tus miv qhia nrog qhov tshwm sim tsis zoo (miv yuav tau ntsib ntau dua ib qho kev tsis zoo).

Table 6: Cov kev tsis zoo tshwm sim thaum kawm hauv feline

Dexmedetomidine n = 122

Xylazine n = 120

Ntuav

70

82

Cov zis tsis txaus

6

kaum ib

Hypersalivation

4

5

Tsis pub dawb tso quav

4

1

Hypothermia

2

1

Raws plab

2

0

Arrhythmia

1

2

Khaws qhov muag

1

0

Cyanosis

1

0

Dyspnea

1

0

Feem ntau pom cov kev tsis zoo tshwm sim yog ntuav ob qho yoo mov thiab pub miv. Lwm yam kev mob tshwm sim tsis tu ncua tau pom hauv miv kho nrog dexmedetomidine suav nrog qaug zog, tsis nco qab, cystitis, thiab cov hlab ntsha tsis zoo.

Ib qho xwm txheej ntawm dyspnea tau tshaj tawm, 43 feeb tom qab dexmedetomidine kev tswj hwm thaum lub qhov ncauj tshuaj xyuas/txheej txheem kho hniav. Ua ntej dexmedetomidine, miv tsis muaj tsos mob tshwm sim, tab sis muaj keeb kwm mob hawb pob thiab ua pa kab mob. Tus miv tau ua tiav kev kho mob.

Feline preanesthesia teb kawm: Kev tshawb fawb txog kev nyab xeeb suav nrog 184 miv (116 tau txais dexmedetomidine; 68 tau txais cov ntsev), 12 lub lis piam mus rau 16 xyoo, thiab sawv cev rau 11 hom tsiaj. Cov lus hauv qab no qhia txog pes tsawg tus miv qhia nrog qhov tshwm sim tsis zoo (miv yuav tau ntsib ntau dua ib qho kev tsis zoo).

Table 7. Cov kev tsis zoo nyob rau lub sijhawm kawm feline preanesthesia

Induction Tshuaj loog

Ketamine

Propofol

Preanesthetic

Ntsev n = 37

Dexmedetomidine n = 64

Ntsev n = 31

Dexmedetomidine n = 52

Emesis

2

nees nkaum

1

12

Cov hnoos qeev daj

kaum ib

9

Txo lub cev kub

4

Retching

1

1

3

Lub plawv yws yws

2

Quav quav

2

Kev raug mob ntawm lub qhov muag

1

Ua pa

1

Kev hloov tus cwj pwm

1

Dej hauv lub raj endotracheal

1

Ib kis ntawm apnea tau tshaj tawm hauv tus miv uas tau txais ketamine ua tus neeg sawv cev induction. Tus miv no xav tau kev tso pa tawm los ntawm qhov pib txheej txheem kom txog rau 30 feeb kom rov zoo thaum tus miv pib ua pa ntawm nws tus kheej. Tus miv zoo tsis muaj teeb meem ntxiv.

QHOV TSEEB TSHAJ PLAWS: Cov xwm txheej tsis zoo hauv qab no tau txais los ntawm kev pom zoo tom qab pom cov tshuaj tsis zoo tshwm sim rau DEXDOMITOR cov tshuaj tsis muaj menyuam los ntawm 2007-2009. Tsis yog txhua qhov kev phom sij raug tshaj tawm. Qee qhov tsis zoo tshwm sim thaum DEXDOMITOR tau siv ib leeg rau sedation; feem ntau tshwm sim thaum DEXDOMITOR tau siv thaum muaj tshuaj loog thiab/lossis lwm yam kev ua kom zoo nkauj. Nws tsis yog ib txwm ua tau los ntseeg tau kwv yees qhov xwm txheej tsis zoo lossis tsim kom muaj kev sib raug zoo nrog cov tshuaj, tshwj xeeb tshaj yog thaum siv tshuaj ntau. Cov xwm txheej tsis zoo hauv qab no tau teev tseg hauv kev txo qis ntawm zaus:

Cov dev: tsis muaj txiaj ntsig rau sedation, tuag, bradycardia, lub plawv nres, apnea, qaug dab peg, ntuav, ua kom tsaug zog ntev, ua kom sov siab, thiab ua kom qeeb.

Miv: tsis muaj txiaj ntsig rau sedation, tuag, lub plawv nres, ntuav, tsaug zog, ua kom lub zog ntev, ua rau lub cev tsis muaj zog, ua kom sov siab, bradycardia, cyanotic mucous membrane, sedation luv luv, thiab ua tsis taus pa.

Cov ntaub ntawv rau tus kheej: Cov tswv yuav tsum ceeb toom rau lawv tus kws kho tsiaj tam sim yog tias lawv miv ntsib teeb meem ua pa vim tsis tshua muaj tshwm sim qeeb ntawm kev pib mob ntsws uas tau cuam tshuam nrog kev tswj hwm ntawm alpha2-adrenergic agonists hauv miv.

Clinical Pharmacology

Dexmedetomidine yog lub zog tsis-narcotic alpha2-adrenoceptor agonist uas ua rau sedation thiab analgesia. Cov teebmeem no yog koob tshuaj nyob ntawm qhov tob thiab ntev. Ntshav siab tau pib nce ntxiv vim yog cov hlab ntsha sab hauv, tom qab ntawd poob qis mus rau qhov qub lossis qis dua qib ib txwm. Vasoconstriction tuaj yeem ua rau cov hnoos qeev ua rau daj ntseg lossis me me cyanotic. Qhov lus teb thawj vasopressor no tau nrog los ntawm kev them nyiaj poob qis hauv lub plawv dhia nruab nrab los ntawm tus kws kho qhov ncauj. Lub plawv dhia ib leeg tuaj yeem xav tias tsis muaj zog thiab hloov pauv hloov pauv hauv kev ua haujlwm ntawm cov leeg mob plawv tuaj yeem tshwm sim, raws li muaj pov thawj los ntawm qib ib thiab qib ob atrioventricular blocks. Lwm yam arrhythmias yuav tshwm sim. Dexmedetomidine kuj ua rau txo qis kev ua pa thiab txo lub cev kub. Qhov loj thiab ntev ntawm qhov txo qis hauv lub cev kub yog nyob ntawm qhov koob tshuaj. Dexmedetomidine ua rau muaj kev nyuaj siab ntawm lub plab zom mov vim qhov txo qis hauv cov leeg ua haujlwm, nce hauv cov ntshav qab zib ntau ntau vim txwv tsis pub tso cov tshuaj insulin, thiab ua rau cov zis ntau ntxiv. Cov leeg nqaij sib tw (twitching) tuaj yeem xav tau hauv qee cov dev sedated nrog dexmedetomidine. Kev ntuav hauv miv tau cuam tshuam nrog alpha2-adrenergic agonist central stimulation ntawm lub hlwb4.

Ua tau zoo

Canine sedation/analgesia kawm tshawb fawb: Dexmedetomidine tau tshuaj xyuas nyob rau hauv daim npog ntsej muag, tswj, ntau qhov chaw tshawb fawb, siv cov pab pawg kho mob sib xws. Kev ua tau zoo tau tshuaj xyuas hauv 200 (ntawm 213) cov neeg siv khoom noj khoom haus zoo, muaj hnub nyoog nruab nrab ntawm 16 lub lis piam thiab 16 xyoos, thiab loj ntawm 4.8 lbs thiab 141 lbs (2.2 kg thiab 64 kg). Cov dev tau nkag mus rau tsev kho mob kws kho tsiaj rau ntau cov txheej txheem uas xav kom ua kom sedation thiab/lossis kev ua kom loog tau txais dexmedetomidine lossis medetomidine ib zaug, los ntawm IV lossis txhaj IM. Cov txheej txheem suav nrog kev kho hniav, duab hluav taws xob, tshem tawm cov tawv nqaij me me, thiab kho mob otitis.

Sedation thiab analgesia tshwm sim tsis pub dhau 5 feeb tom qab IV dexmedetomidine, thiab tsis pub dhau 15 feeb tom qab IM dexmedetomidine, nrog cov txiaj ntsig siab tshaj kwv yees li ntawm 15 lossis 30 feeb, feem. Cov teebmeem ploj los ntawm kwv yees li ob teev tom qab kev tswj hwm IV, thiab los ntawm peb teev siv IM txoj kev. Dexmedetomidine thiab medetomidine pom cov txiaj ntsig zoo sib xws hauv tsev kho mob.

Lub plawv dhia tau ntsuas los ntawm auscultation. Bradycardia tshwm sim tsis pub dhau 5 txog 15 feeb tom qab IV dexmedetomidine lossis medetomidine, thiab tsis pub dhau 15 txog 30 feeb tom qab muab tshuaj rau IM. Sixty-plaub dexmedetomidine kho cov dev thiab 50 medetomidine-kho dev tau pom nrog bradycardia.

Cov teeb meem tsis zoo thaum lub sijhawm tshawb fawb suav nrog ua rau lub plawv dhia tsis meej, ua tsis taus pa, ua kom lub cev tsis muaj zog, thiab tsis muaj txiaj ntsig (saib QHOV TSEEB YUAV TSUM PAUB TXOG).

Kaum tus dev tau txais cov tshuaj sib xws thaum lub sijhawm tshawb fawb, suav nrog amoxicillin, cephalexin, triamcinolone, methyl-prednisolone acetate, neomycin, nystatin, thiostrepton, acepromazine, atropine, thiab atipamezole.

Cov txiaj ntsig ntawm txoj kev tshawb fawb no qhia pom tias dexmedetomidine ua rau muaj qib txaus ntawm kev ua kom loog thiab ua kom loog rau kev kuaj mob thiab txheej txheem, txheej txheem phais me me, thiab txheej txheem kho hniav me.

Canine preanesthesia teb kawm: Kev siv dexmedetomidine ua qhov ua kom zoo nkauj tau raug tshuaj xyuas hauv kev tswj hwm, ntau qhov chaw tshawb fawb, siv cov pab pawg sib kho. Kev ua tau zoo tau tshuaj xyuas hauv 192 tus neeg noj qab nyob zoo, tus tswv muaj tus dev, nruab nrab ntawm 5 hlis txog 15 xyoos, hnyav 4 txog 196 lbs (2 kg txog 89 kg). Cov dev tau txais IM dexmedetomidine lossis saline ua qhov ua kom loog rau kev tso tshuaj loog. Txhua tus dev raug ntxias los ntawm kev siv tshuaj loog; ib nrab ntawm cov dev tau tswj hwm nrog kev nqus tshuaj loog. Cov txheej txheem suav nrog orchiectomy, ovariohysterectomy, phais tawv nqaij, duab hluav taws xob, kuaj lub cev, txheej txheem kho hniav, tu pob ntseg, kho qhov quav qhov quav, thiab tu cev.

Piv rau kev tswj cov ntsev, dexmedetomidine IM txo qis cov tshuaj xav tau los ntawm 30-36% (ntawm 125 mcg/m2) thiab los ntawm 38-61% (ntawm 375 mcg/m2). Kev nqus cov tshuaj loog xav tau 40-60% tsawg dua rau cov dev dexmedetomidine-preanesthetized. Tus naj npawb ntawm cov dev nrog cov tsos mob ntawm tus mob tau tsawg tsawg kawg 30 feeb tom qab tus txheej txheem hauv dev kho nrog 375 mcg/m2dexmedetomidine, piv rau kev tswj cov ntsev.

Lub sijhawm rov ua haujlwm yog nyob ntawm qhov xav tau, qhov nruab nrab 15-32 feeb rau kev nthuav tawm thiab 71-131 feeb kom sawv rov qab los (lub sijhawm ntev dua sib npaug rau ntau dua dexmedetomidine koob). Lub sijhawm rov zoo tseem vam khom rau kev siv tshuaj loog. Lub sijhawm rov qab los tom qab kev siv barbiturate tau ntev dua (30 feeb rau kev nthuav tawm thiab 118 feeb rau sawv), piv rau cov dev ntxias nrog propofol (23 feeb rau extubation thiab 84 feeb rau sawv).

Lub plawv dhia tsis xwm yeem tau saib xyuas los ntawm ECG. Dexmedetomidine-kho cov dev tau pom ntau zaus nrog tsawg kawg ib qho xwm txheej ntawm arrhythmia piv rau kev tswj cov ntsev. Qhov feem ntau pom kev mob plawv tsis zoo yog bradycardia, 1stthiab 2ua nddegree AV block, thiab qhov ntswg ntes. Lwm qhov tsis tshua pom muaj lub plawv dhia tsis tu ncua suav nrog cov hlab ntsws ntxov ua ntej (VPCs), supraventricular ntxov ntxov ua haujlwm, 3rd uadegree AV block, thiab sinus ncua.

Cov xwm txheej tsis zoo suav nrog bradycardia, tachycardia, VPCs, ntuav, raws plab, tso zis tsis tso zis, thiab raug mob rau tus kheej (saib QHOV TSEEB TSHAJ PLAWS).

Cov txiaj ntsig ntawm kev tshawb fawb thaj tsam preanesthesia qhia pom tias dexmedetomidine muab tshuaj loog-tsau tshuaj, ua kom loog, thiab ua kom loog thaum lub sijhawm ua cov tshuaj loog.

Feline sedation/analgesia kev kawm: DEXDOMITOR tau tshuaj xyuas nyob rau hauv daim npog ntsej muag, tswj, ntau qhov chaw kawm hauv thaj chaw, siv pab pawg kho mob sib xws. Kev ua tau zoo tau tshuaj xyuas hauv 242 tus neeg siv cov miv, suav nrog hnub nyoog nruab nrab ntawm 6 hli thiab 17 xyoo, thiab loj ntawm 2.3 thiab 9.6 kg (5 thiab 21 lbs). Cov miv tau lees paub hauv tsev kho mob rau ntau yam txheej txheem xav tau kev tswj hwm, ua kom loog, thiab/lossis kev ua kom loog tau raug xaiv mus rau pawg kho mob thiab muab dexmedetomidine (122 miv) lossis xylazine (120 miv) ib zaug los ntawm txhaj IM. Cov txheej txheem ua tiav siv dexmedetomidine suav nrog kev kho hniav, duab hluav taws xob, phais me me, kho qhov txhab, kho ntshav los yog tso zis tso zis tso zis, tattooing, tso microchip, thiab tu cev.

Sedation thiab analgesia tshwm sim li ntawm 5 txog 15 feeb thiab cov txiaj ntsig siab tshaj tau pom 30 feeb tom qab dexmedetomidine. Cov txheej txheem tau yooj yim ua hauv 91% ntawm cov miv pib 30 feeb tom qab dexmedetomidine. Sedative thiab analgesic teebmeem waned los ntawm peb teev tom qab dexmedetomidine.

Cov cim ntawm sedation tau tob dua rau cov miv tau txais dexmedetomidine piv rau cov uas tau txais xylazine. Tsis muaj qhov sib txawv hauv tsev kho mob tau pom ntawm dexmedetomidine thiab xylazine nrog rau kev mob plab lossis hloov pauv lub cev. Lub plawv dhia, ua pa nyuaj, thiab qhov kub tau txo qis. Bradycardia tau pom hauv 5 txog 15 feeb thiab lub plawv dhia ntawm ≦ 70 neeg ntaus/feeb tau pom hauv 18% ntawm cov miv. Feem ntau pom kev mob plawv tsis txaus ntseeg ntsuas nrog ECG yog atrioventricular kev sib cais thiab khiav tawm rhythms, ua raws li ob peb qhov xwm txheej ntawm cov ua ntej ntxov thiab ib qho tshwm sim ntawm atrioventricular block. Cov pa oxygen txaus, xim xim ua kua, lub sijhawm ua kom cov hlab ntshav ntxiv, lub plawv dhia, ua pa tob tob thiab tus qauv, thiab cov lus teb ntawm tus tsiaj mus rau kev txhaj tshuaj tau txais txiaj ntsig zoo. Txhua tus miv tau zoo los ntawm kev hloov pauv los ntawm dexmedetomidine.

Cuaj caum-xya qhov xwm txheej tsis zoo tau tshaj tawm tom qab dexmedetomidine. Feem ntau tau tshaj tawm cov kev tsis zoo suav nrog ntuav (70), tso zis tso zis tsis txaus (6), ua rau lub cev tsis muaj zog (4), tso quav tsis tuaj yeem ua haujlwm (4), ua kom sov qis (2), thiab raws plab (2) (saib QHOV TSEEB YUAV TSHUAJ).

Cov txiaj ntsig ntawm txoj kev tshawb fawb no qhia pom tias dexmedetomidine ua rau muaj qib txaus ntawm kev ua kom loog thiab ua kom loog rau kev kuaj mob thiab txheej txheem, txheej txheem phais me me, thiab txheej txheem kho hniav me.

Feline preanesthesia teb kawm: Kev siv dexmedetomidine ua qhov ua kom zoo nkauj tau raug tshuaj xyuas hauv daim npog ntsej muag, tswj hwm, ntau qhov chaw tshawb fawb, siv pab pawg kho mob sib xws. Kev ua tau zoo tau tshuaj xyuas hauv 182 kev noj qab haus huv, cov miv muaj tus miv, ntawm 12 lub lis piam thiab 16 xyoos, hnyav 2.10 txog 18.8 lbs (0.9 kg txog 8.5 kg). Preanesthetic/induction tshuaj regimens suav nrog saline/ketamine, dexmedetomidine/ketamine, saline/propofol, thiab dexmedetomidine/propofol. Txhua tus miv tau muab tso rau ua ntej txoj haujlwm. Cov tshuaj loog ua kom loog (isoflurane) tau ntxiv rau cov txheej txheem ntev dua (> 15 feeb) thiab tuaj yeem muab ntxiv thaum cov txheej txheem luv dua yog tias tus kws kho tsiaj pom tias nws tsim nyog. Cov txheej txheem suav nrog ovariohysterectomy, orchiectomy, onychectomy, thiab tu hniav.

Dexmedetomidine IM tau tswj hwm ntawm 40 mcg/kg ua ntej pib nrog ketamine ua rau muaj kev faib ua feem ntau ntawm cov miv uas tau ua tiav kev nqus dej piv rau cov ntsev (ua tiav ntawm 89.5% thiab 10.7%, feem).

Miv preanesthetized nrog dexmedetomidine IM xav tau 48.9% tsawg dua propofol rau kev ua kom zoo dua piv rau miv uas tau txais cov ntsev. Qhov xav tau tshuaj loog yog 35-44% tsawg dua rau dexmedetomidine preanesthetized miv. Lub sijhawm rov qab los tom qab ketamine thiab propofol induction qhov nruab nrab 36 thiab 38 feeb rau extubation thiab 161 thiab 131 feeb rau sawv, ntsig txog rau dexmedetomidine pawg kho.

Dexmedetomidine (ua raws li ketamine lossis propofol) ua rau ECG qhov txawv txav hauv qab no (hauv kev txiav txim kom tsawg): sinus bradycardia, sinus arrhythmia, 1stqib atrioventricular (AV) thaiv, ntev QT ncua, qhov ntswg tso tseg, lub plawv dhia ntxov ntxov tso tawm, 2ua ndqib AV thaiv, khiav nrawm/rhythms, thiab supraventricular ntxov ntxov depolarizations. Cov miv uas kho Dexmedetomidine muaj lub plawv qis dua, ua pa nyuaj, thiab lub cev kub piv rau kev tswj cov ntsev txuas ntxiv mus los ntawm lub sijhawm rov zoo.

Rau caum-rau qhov xwm txheej tsis zoo tau tshaj tawm tom qab dexmedetomidine. Feem ntau tau tshaj tawm cov xwm txheej tsis zoo yog: ntuav (32), daj ntseg daj (20), poob lub cev kub (4), thiab rov qab los (4). (Saib ADVERSE REACTIONS).

Kev Nyab Xeeb Tsiaj:

Canine kev nyab xeeb kawm: Hauv ntau txoj kev kawm txog kev nyab xeeb, dexmedetomidine tau muab rau ntawm 0, 1, 3 lossis 5 zaug (X) qhov kev pom zoo IV thiab IM koob tshuaj ntawm 3 hnub sib law liag rau tag nrho ntawm 36 noj qab nyob zoo, cov tub ntxhais hluas beagles. Ob pawg ntxiv tau muab 3X koob tshuaj dexmedetomidine (IV lossis IM) ua raws li peb 1X koob ntawm tus neeg sawv cev thim rov qab, atipamezole (ANTISEDAN), txhua 30 feeb. Qhov no tau rov ua dua tag nrho ntawm 3 hnub. Tsis muaj neeg tuag tshwm sim thaum kawm.

1X koob tshuaj pab pawg: Ntawm qhov koob tshuaj pom zoo, ua kom lub sijhawm ntev dua 3 teev. Thaum lub caij ua kom loog, cov leeg ntswj tau tshwm sim ib ntus, thiab txo qhov kub thiab txias, ua pa thiab lub plawv dhia tau pom hauv txhua tus tsiaj. Cov tub ntxhais kawm teb qeeb rau lub teeb pom pom tsis tu ncua li 15 feeb tom qab txhaj tshuaj hauv ib ntawm kaum ob tus dev. Qib thib ob atrioventricular (AV) thaiv tau pom hauv ib ntawm kaum ob tus dev.

3X koob tshuaj pab pawg: Ntawm 3 zaug koob tshuaj pom zoo, lub sijhawm ua kom lub siab nyob nruab nrab ntawm ob thiab yim teev. Thaum lub caij ua kom loog, cov leeg ntswj tau tshwm sim, thiab qhov kub thiab txias, ua pa nyuaj, thiab lub plawv dhia qis hauv txhua tus dev. Cov menyuam kawm ntawv lub teeb pom kev zoo tau txo qis mus txog 90 feeb hauv plaub ntawm kaum ob tus dev. Kev ntuav tau pom hauv ob ntawm kaum ob tus dev. Ib tus dev tau ntsib thawj thiab qib thib ob AV thaiv; qib thib ob AV thaiv tau pom hauv peb ntawm kaum ob tus dev. Kev nce siab ntawm alanine aminotransferase (ALT) tau pom hauv ib tus dev, tsis muaj keeb kwm hloov pauv rau lub siab.

5X koob tshuaj pab pawg: Ntawm 5 zaug koob tshuaj pom zoo, lub sijhawm ua kom sedation nyob nruab nrab ntawm plaub thiab yim teev. Cov leeg ntswj, txo qhov kub thiab txias, ua pa nyuaj, thiab lub plawv dhia tau pom hauv txhua tus dev. Tsis muaj tus tub kawm ntawv tau teb rau hauv rau ntawm kaum ob tus dev (IV) txog li 1.5 teev; txo qis me nyuam kawm ntawv lub teeb pom kev zoo tau pom txog li 60 feeb hauv ob ntawm kaum ob tus dev (IM). Kev ntuav tau pom hauv ib ntawm kaum ob tus dev. Thawj thiab qib thib ob AV thaiv tau pom hauv ib ntawm kaum ob tus dev. Kev nce siab ntawm ALT tau pom hauv 3 ntawm 12 tus dev, tsis muaj kev hloov pauv keeb kwm rau lub siab.

Dexmedetomidine tau qhia txog koob tshuaj tiv thaiv cuam tshuam nrog nws cov chaw muag tshuaj thaum siv IV lossis IM rau cov dev noj qab nyob zoo ntawm koob tshuaj txog li tsib zaug ntawm koob tshuaj pom zoo.

Canine kev nyab xeeb kawm nrog anticholinergic: Hauv lwm qhov kev tshawb fawb txog kev nyab xeeb, ib ntawm peb koob tshuaj IM anticholinergic tshuaj lossis ntsev tau muab 10 feeb ua ntej, tib lub sijhawm, lossis 15 feeb tom qab 500 mcg/m2IM dexmedetomidine hmoov Cov tshuaj anticholinergic tau muab rau kev tiv thaiv lossis kho mob dexmedetomidine vim txo qis hauv lub plawv. Hauv kev tsim qauv hla, 18 tus dev tau siv tag nrho ntawm 72 qhov kev sim, txhawm rau ntsuas kev nyab xeeb ntawm dexmedetomidine siv nrog tshuaj anticholinergic.

Cov dev tau siv rau kev khaws cov ntaub ntawv txuas ntxiv ECG. Cov xwm txheej hauv qab no tau sau tseg thaum kawm (qee tus dev tau ntsib ntau dua ib qho kev mob plawv).

Rooj 8: Kev kaw qhov tsis txaus ntseeg thaum lub sij hawm kawm canine kev nyab xeeb kev kawm*

Hom arrhythmia

Cov nab npawb (ntawm 18)

Qib ob AV thaiv

18

Supraventricular tachycardia (SVT) lossis SVPCs

16

Ventricular khiav dim

16

Ventricular ntxov ntxov contractions

14

Qib thib peb AV thaiv

6

Idioventricular rhythms

1

Paroxysmal VT

1

Ventricular loj heev; SVPCs; pulse alternans

yog flonase ib decongestant

1

Kev sib tshuam khiav dim

1

*Cov lus tsis cuam tshuam txog kev mob plawv mus rau qhov muaj lossis tsis muaj anticholinergic

Qhov tshwm sim ntawm arrhythmias tsis cuam tshuam nrog kev muaj lossis tsis muaj cov tshuaj anticholinergic. Arrhythmias tau hloov pauv (txawm hais tias nquag dhau lub sijhawm hauv qee tus dev), rov qab mus rau theem pib hauv 55 feeb tom qab dexmedetomidine. Tsis muaj tus dev xav tau kev kho mob ntsig txog cov kev mob plawv no, thiab tsis muaj ib qho ntawm cov kev mob plawv no tsis muaj zog lossis cuam tshuam tsis zoo rau txhua qhov xwm txheej ntawm ib tus dev hauv txoj kev tshawb fawb.

Dexmedetomidine tsis muaj anticholinergic: Tsis muaj tshuaj anticholinergic, thiab ntxiv rau kev mob plawv, dexmedetomidine tsim cov chaw kho mob cuam tshuam nrog kev ntsuas tseem ceeb txo qis hauv lub plawv, ua pa tawm, lub plawv dhia tawm, kub hauv lub ntsws, thiab sib xyaw cov leeg ntshav. Kev txheeb xyuas qhov tseem ceeb hauv cov ntshav ntshav siab, cov hlab ntshav hlab ntshav hlab ntshav siab, lub hauv nruab nrab cov hlab ntshav siab, thiab cov hlab ntshav tiv thaiv kab mob tau sau tseg. Tsis muaj dev tau ntsib hypotension. Dexmedetomidine tended kom ua rau cov hlab ntshav tiv taus. Dexmedetomidine ib leeg tsis muaj cov txiaj ntsig tseem ceeb ntawm kev ntsuas ntshav siab, cov hlab ntshav pH, cov pa roj carbon dioxide nruj, thiab cov pa oxygen nruj.

Dexmedetomidine ntxiv rau anticholinergic: Ob qho ntawm ob qho tshuaj anticholinergic siab dua tau ua tiav hauv kev tiv thaiv lossis kho mob dexmedetomidine vim txo qis hauv lub plawv. Anticholinergic (koob tshuaj ntau dua) muab tom qab dexmedetomidine ua rau muaj kev nce ntxiv hauv qhov tshwm sim ntawm ntau yam kev mob plawv tsis zoo, tshwj xeeb tshaj yog qib ob AV thaiv. Thaum cov tshuaj anticholinergic ntau dua tau muab rau tib lub sijhawm lossis 15 feeb tom qab dexmedetomidine, nce ntau hauv lub plawv (p.<0.01) and blood pressure (p<0.05) were seen. Increases were dose related; the highest anticholinergic dose elicited more frequent arrhythmias and larger increases in heart rate and blood pressure.

Hauv qhov xaus, kev siv tshuaj anticholinergic me ntsis ua ntej dexmedetomidine ua tau zoo tshaj plaws rau kev tiv thaiv dexmedetomidine-txo qis lub plawv dhia hauv dev. Kev siv tshuaj anticholinergics niaj hnub muab ib txhij nrog, lossis tom qab dexmedetomidine, tsis pom zoo.

Feline kev nyab xeeb kawm: Hauv ntau txoj kev tshawb fawb txog kev nyab xeeb, DEXDOMITOR tau muab tshuaj intramuscularly (IM) ntawm 1X, 3X, thiab 5X (40, 120, thiab 200 mcg/kg) qhov pom zoo koob tshuaj ntawm 40 mcg/kg rau 3 hnub sib law los noj qab haus huv miv, 6 rau 8 hli. Pawg tswj hwm tau txais cov khoom lag luam tsheb ua cov placebo (0X). Tsis tau pom kev tuag. Qhov tob thiab ntev ntawm kev ua kom sedation yog nyob ntawm qhov koob tshuaj, nyob ntev li ntawm 2 teev hauv 1X pab pawg, 2 txog 4 teev hauv pab pawg 3X, thiab ntau dua 8 teev hauv 5X pab pawg. Tus neeg sau tus nqi qis tshaj plaws hauv lub plawv yog 60 ntaus/feeb thiab tshwm sim hauv 5X koob tshuaj pab pawg (2 tus miv). Lub plawv dhia tsis xwm yeem tshwm sim los ntawm kev sib cais sib cais khiav tawm nrog cov ntu ntawm kev sib tshuam khiav mus los tau pom nyob rau lub sijhawm qis ntawm lub plawv dhia lossis tom qab qhov ntswg tso tseg hauv txhua pawg dexmedetomidine. Feem ntau qhov kev mob plawv tsis tuaj yeem pom tom qab 1 txog 2 teev. Atrioventricular block tsis pom. Qhov xwm txheej ntawm arrhythmias tsis cuam tshuam nrog koob tshuaj; txawm li cas los xij, ntau tus miv tau cuam tshuam los ntawm kev mob plawv tsis zoo nyob rau hnub thib peb ntawm kev kho mob, piv rau thawj ob hnub ntawm txoj kev tshawb fawb. Qhov txo qis hauv kev ua pa, tab sis tsis yog lub sijhawm, yog nyob ntawm qhov koob tshuaj. Qhov kub ntawm qhov quav txo qis hauv txhua pawg dexmedetomidine kho, nrog qhov kub qis tshaj hauv pab pawg 5X ntawm 8 teev rau tag nrho peb hnub. Ob tug miv ntuav (40 thiab 120 mcg/kg). Corneal opacity tau sau tseg hauv txhua pawg dexmedetomidine, tau hloov pauv, cuam tshuam nrog koob tshuaj thiab ntev npaum li cas ntawm kev ua kom loog, thiab tau suav tias yog tsis muaj lubrication nrog ntsais ntsais thaum lub sij hawm sedation. Hematology thiab ntshav tshuaj tsis raug cuam tshuam los ntawm kev kho mob. Kev txhaj tshuaj tiv thaiv qhov chaw tau zoo, nrog rau qhov mob txhab me me sawv cev ntawm IM txheej txheem txhaj tshuaj. Kev tshuaj xyuas tag nrho thiab keeb kwm ntawm tag nrho lwm cov ntaub so ntswg tsis tau qhia txog qhov txawv txav cuam tshuam nrog DEXDOMITOR kev tswj hwm.

Dexmedetomidine tau qhia txog koob tshuaj tiv thaiv cuam tshuam nrog nws cov chaw muag tshuaj thaum siv IM rau cov miv noj qab nyob zoo ntawm koob tshuaj txog li tsib zaug ntawm koob tshuaj pom zoo.

Feline kev mob siab rau kawm: IM DEXDOMITOR tau muab tshuaj ib zaug ntawm 10X (400 mcg/kg) qhov koob tshuaj pom zoo ntawm 40 mcg/kg rau 3 tus poj niam thiab 3 tus txiv neej 7 hli miv. Tsis tau pom kev tuag. Sedation tau pom nyob rau hauv 15 feeb ntawm kev txhaj tshuaj thiab tau ntev li tsawg kawg 4 teev nrog kev rov zoo tag nrho sau tseg ntawm 8 thiab 24 teev tom qab txhaj tshuaj. Kev soj ntsuam tsis tu ncua ntawm lub cev qhuav dej thiab tsis pom kev, miosis, tawv nqaij daj thiab gingiva, tso zis, thiab tso dej tawm ntawm qhov muag tau pom hauv qee tus tsiaj. Kev ntuav tau pom 7 txog 11 teev tom qab noj tag nrho tab sis ib tus tsiaj. Kev txo qis hauv lub plawv nrog rau ncua sijhawm PQ thiab QT feem ntau tau tshaj tawm 2 txog 4 teev tom qab txhaj tshuaj. Tsis muaj atrioventricular (AV) thaiv lossis khiav tawm rhythms tau sau tseg. Hauv ib tus miv, qhov xwm txheej thiab thim rov qab ua rau lub cev tsis sib haum xeeb tau pom ntawm 1 thiab 2 teev tom qab noj tshuaj uas tau txiav txim siab thib ob rau bradycardia. Tus kab mob ua pa qis me ntsis thiab txo qhov kub hauv qhov quav tau pom 4 txog 8 teev tom qab noj tshuaj. Kev soj ntsuam tau rov zoo li qub los ntawm 24 teev tom qab txhaj tshuaj. Cov kab mob me me ua rau pom keeb kwm ntawm qhov chaw txhaj tshuaj yog tus sawv cev ntawm IM txheej txheem txhaj tshuaj. Tsis muaj kev hloov pauv ntsig txog kev kho mob tau pom hauv hematology. Kev nce siab me me hauv qee qhov kev kuaj mob ALT, AST, thiab CK, tau pom 24 teev tom qab txhaj tshuaj, nrog rau kev rov zoo los ntawm 48 teev. Tag nrho cov protein, qib albumin thiab globulin tau qis qis me ntsis hauv ib tus miv 48 teev tom qab txhaj tshuaj.

Cov ntaub ntawv khaws cia: Khaws ntawm chav sov tswj 15-30 ° C (59-86 ° F). Tiv thaiv kom khov. Hauv kev siv lub neej txee: 90 hnub ntawm 25 ° C (77 ° F).

Yuav Muab Li Cas

DEXDOMITOR 0.5 mg/mL muab rau hauv 10-ml, ntau lub vials uas muaj 0.5 mg ntawm dexmedetomidine hydrochloride ib mL.

Cov neeg ua tim khawv

(1) Ko JCH, Fox SMF, Mandsager RE. Cov teebmeem ntawm kev saib xyuas ua ntej atropine ntawm qhov tshwm sim ntawm medetomidine-induced bradycardia hauv dev. J Am Vet Med Assoc 2001; 218: 52-58.

(2) Alibhai HIK, Clarke KW, Lee YH, li al. Cardiopulmonary teebmeem ntawm kev sib txuas ntawm medetomidine hydrochloride thiab atropine sulphate hauv dev. Vet Rec Xyoo 1996; 138: 11-13.

(3) Luv, CE. Cov teebmeem ntawm kev kho anticholinergic ntawm lub plawv thiab lub tshuab ua pa hauv cov dev sedated nrog medetomidine. Vet Rec 1991; 129: 310-313.

(4) Hikasa Y, Akiba T, Iino Y li al. Central alpha-adrenoceptor subtypes koom nrog hauv txoj kev emetic hauv miv. Eur J Pharmacol 1992; 229: 241-251.

LAWV. Patent Tsis. 4,910,214

CONTAMINATOR® ibyog lub cim lag luam ntawm Orion Corporation.

Mfd los ntawm: Orion Pharma, Orion Corporation, Espoo, Finland

Nyob deb ntawm: Zoetis Inc., Kalamazoo, MI 49007

Ua hauv Finland

Kho dua: Peb Hlis 2015

122691-6

CPN: 3690241.3

ZOETIS INC Dr.
333 PORTAGE STREET, KALAMAZOO, MI, 49007
Xov tooj: 269-359-4414
Kev Pabcuam Cov Neeg Siv Khoom: 888-963-8471
Lub Vev Xaib: www.zoetis.com
Txhua lub dag zog tau ua kom ntseeg tau qhov tseeb ntawm Dexdomitor 0.5 cov ntaub ntawv tshaj tawm saum toj no. Txawm li cas los xij, nws tseem yog lub luag haujlwm ntawm cov neeg nyeem kom paub lawv tus kheej nrog cov ntaub ntawv khoom lag luam muaj nyob hauv Asmeskas cov khoom lag luam daim ntawv lo lossis pob ntim.

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